Disposition of cefpodoxime proxetil in healthy volunteers and patients with impaired renal function
نویسندگان
چکیده
منابع مشابه
Simultaneous spectrophotometric determination of cefpodoxime proxetil and ofloxacin in tablets
The present manuscript describe simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of cefpodoxime proxetil and ofloxacin in combined tablet dosage form. Absorbance ratio method uses the ratio of absorbances at two selected wavelengths, one which is an isoabsorptive point and other being the λ-max of one of the two components. ...
متن کاملFormulation and in vitro characterization of cefpodoxime proxetil gastroretentive microballoons
BACKGROUND AND THE PURPOSE OF THE STUDY The objective of the present work was to improve bioavailability of cepodoxime proxetil through gastroretentive microballoon formulation. METHODS Microballoons of cefpodoxime proxetil were formulated by solvent evaporation and diffusion method employing hydroxypropylmethyl cellulose (HPMC) and ethyl cellulose (EC) polymers and characterized for particle...
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The disposition of roxithromycin, an investigational macrolide antibiotic, was evaluated in 20 subjects, 10 with normal renal function (creatinine clearance [CLCR] of 116 +/- 17 ml/min [mean +/- standard deviation]) and 10 with severely impaired renal function (CLCR of 10.2 +/- 2.6 ml/min) after a single 300-mg oral dose. Plasma concentration-time data were analyzed in terms of a one- or two-co...
متن کاملCefpodoxime Proxetil Floating Microspheres: Formulation and In Vitro Evaluation
The objective of the present study was to develop floating microspheres of cefpodoxime proxetil in order to achieve an extended retention in the upper GIT, which may result in enhanced absorption and thereby improved bioavailability. The microspheres were prepared by non-aqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose (HPMC K 15 M), ethyl cellulo...
متن کاملComparison of cefprozil, cefpodoxime proxetil, loracarbef, cefixime, and ceftibuten.
OBJECTIVE To discuss the pharmacokinetics, spectrum of activity, clinical trials, and adverse effects of cefprozil, cefpodoxime proxetil, loracarbef, cefixime, and ceftibuten, an investigational cephalosporin. DATA SOURCES Literature was identified by a MEDLINE search from 1986 to January 1995. STUDY SELECTION Randomized, controlled studies were selected for evaluation; however, uncontrolle...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1992
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.36.1.126